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KMID : 0931320180180040247
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대한상부위장관.헬리코박터학회지
2018 Volume.18 No. 4 p.247 ~ p.257
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Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials
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Hwang Young-Jae
Kim Na-Young
Kim Sung-Eun
Baik Gwang-Ho
Lee Ju-Yup
Park Kyung-Sik
Joo Young-Eun
Myung Dae-Sung
Kim Hyeon-Ju
Song Hyun-Joo
Kim Heung-Up
Nam Kwang-Woo
Shin Jeong-Eun
Kim Hyun-Jin
Kim Gwang-Ha
Lee Jong-Chan
Lim Seon-Hee
Seo Geom-Seog
Choi Suck-Chei
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Abstract
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Background/Aims: The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016∼2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016∼2017.
Materials and Methods: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016∼2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed.
Results: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016∼2017 (51.6%; 1,293/2,506; P＜0.001). The prevalence of AG decreased from 2011 to 2016∼2017 (P=0.018), but that of IM increased (P＜0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016∼2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016∼2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level.
Conclusions: The difference in prevalence trends of AG and IM between 2016∼2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection.
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KEYWORD
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ophic gastritis, Helicobacter pylori, Metaplasia, Prevalence, Risk factors
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